Pendaries Caroline, Tronchère Hélène, Plantavid Monique, Payrastre Bernard
Inserm U563, Centre de Physiopathologie de Toulouse Purpan, Département d'oncogenèse et signalisation dans les cellules hématopoïétiques, Hôpital Purpan, 31059 Toulouse Cedex, France.
FEBS Lett. 2003 Jul 3;546(1):25-31. doi: 10.1016/s0014-5793(03)00437-x.
Phosphoinositides (PIs) play an essential role in diverse cellular functions. Their intracellular level is strictly regulated by specific PI kinases, phosphatases and phospholipases. Recent discoveries indicate that dysfunctions in the control of their level often lead to pathologies. This review will focus on some human diseases whose etiologies involve PI-metabolizing enzymes. The role of PTEN (phosphatase and tensin homolog deleted on chromosome ten) in cancer, the impact of the Src homology 2-containing inositol-5-phosphatase phosphatases in acute myeloid leukemia or diabetes, the involvement of myotubularin family members in genetic diseases and the implication of OCRL1 in Lowe syndrome will be emphasized. We will also review how some bacterial pathogens have evolved strategies to specifically manipulate the host cell PI metabolism to efficiently infect them.
磷酸肌醇（PIs）在多种细胞功能中发挥着至关重要的作用。它们在细胞内的水平受到特定的PI激酶、磷酸酶和磷脂酶的严格调控。最近的发现表明，其水平控制的功能障碍常常导致疾病。本综述将聚焦于一些病因涉及PI代谢酶的人类疾病。将重点阐述PTEN（第10号染色体缺失的磷酸酶和张力蛋白同源物）在癌症中的作用、含Src同源2结构域的肌醇-5-磷酸酶在急性髓系白血病或糖尿病中的影响、肌管素家族成员在遗传疾病中的参与以及OCRL1在 Lowe综合征中的作用。我们还将综述一些细菌病原体如何进化出专门操纵宿主细胞PI代谢以有效感染宿主的策略。
