Johnston Anne M, Pirola Luciano, Van Obberghen Emmanuel
INSERM Unit 145, IFR 50, Faculty of Medicine, Nice, France.
FEBS Lett. 2003 Jul 3;546(1):32-6. doi: 10.1016/s0014-5793(03)00438-1.
The insulin receptor substrate (IRS) proteins act as important mediators of insulin action. Their regulation serves to augment the specificity of the insulin signalling cascade. They can be regulated--both positively and negatively--at the level of phosphorylation, and signalling through these proteins can be further modulated through the actions of SOCS (suppressor of cytokine signalling) proteins. Understanding the mechanisms of IRS regulation will provide further insight into the pathophysiology of insulin resistance and type 2 diabetes.
胰岛素受体底物（IRS）蛋白是胰岛素作用的重要介质。它们的调节作用有助于增强胰岛素信号级联反应的特异性。它们可在磷酸化水平受到正向和负向调节，并且通过这些蛋白的信号传导可通过细胞因子信号抑制蛋白（SOCS）的作用进一步调节。了解IRS调节机制将为深入了解胰岛素抵抗和2型糖尿病的病理生理学提供更多信息。
