Ashiuchi Makoto, Kuwana Eriko, Komatsu Kazuya, Soda Kenji, Misono Haruo
Department of Bioresources Science, Kochi University, Nankoku, Japan.
FEMS Microbiol Lett. 2003 Jun 27;223(2):221-5. doi: 10.1016/S0378-1097(03)00381-1.
Bacillus subtilis possesses two isogenes encoding glutamate racemases, the poly-gamma-glutamate synthesis-linking Glr enzyme and the YrpC isozyme, and produces abundant amounts of the Glr enzyme. The YrpC isozyme, but not the Glr enzyme, was found to influence the activity of DNA gyrase, as did the MurI-type glutamate racemase of Escherichia coli, which is involved in peptidoglycan synthesis during cell division.
枯草芽孢杆菌拥有两个编码谷氨酸消旋酶的同基因，即与聚γ-谷氨酸合成相关的Glr酶和YrpC同工酶，并且能大量产生Glr酶。研究发现，YrpC同工酶而非Glr酶会影响DNA促旋酶的活性，就像大肠杆菌中参与细胞分裂过程中肽聚糖合成的MurI型谷氨酸消旋酶一样。
