白细胞介素-10作为一种中枢神经系统治疗药物：血脑屏障/血脊髓屏障的阻碍
Interleukin-10 as a CNS therapeutic: the obstacle of the blood-brain/blood-spinal cord barrier.
作者信息
Kastin Abba J, Akerstrom Victoria, Pan Weihong
机构信息
VA Medical Center and Tulane University School of Medicine, 1601 Perdido Street, New Orleans, LA 70112-1262, USA.
出版信息
Brain Res Mol Brain Res. 2003 Jun 10;114(2):168-71. doi: 10.1016/s0169-328x(03)00167-0.
Interleukin (IL)-10 exerts beneficial effects on the central nervous system (CNS) after peripheral administration, but its penetration across the blood-brain barrier (BBB) has not been quantified. We show that 125I-IL-10 is stable in circulating blood but does not cross the intact BBB after intravenous delivery. Thus, peripheral IL-10 probably can serve as a CNS therapeutic only when the BBB is disrupted.
外周给予白细胞介素（IL）-10 对中枢神经系统（CNS）具有有益作用，但其穿过血脑屏障（BBB）的情况尚未得到量化。我们发现，125I-IL-10 在循环血液中稳定，但静脉注射后不能穿过完整的血脑屏障。因此，外周 IL-10 可能只有在血脑屏障被破坏时才能作为中枢神经系统治疗药物。
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