儿童期起病的系统性红斑狼疮

[Childhood-onset systemic lupus erythematosus].

作者信息

Bader-Meunier B, Quartier P, Deschênes G, Cochat P, Haddad E, Koné-Paut I, Leblanc T, Prieur A M, Salomon R, Bodemer C, Lévy M

机构信息

Service de pédiatrie générale, hôpital de Bicêtre, 78, rue du Général-Leclerc, 94276 Le Kremlin-Bicêtre, France.

出版信息

Arch Pediatr. 2003 Feb;10(2):147-57. doi: 10.1016/s0929-693x(03)00313-0.

DOI:10.1016/s0929-693x(03)00313-0

PMID:12829358

Abstract

Systemic Lupus Erythematosus (SLE) remains a challenging autoimmune disease in term of etiology, pathogenesis and treatment. It is estimated that 10-17% of lupus patients present before the age of 16. SLE in children appears to have more severe organ involvement than in adults. The outcome of childhood SLE has improved during the last decade, but the morbidity remains high.

摘要

系统性红斑狼疮（SLE）在病因、发病机制和治疗方面仍然是一种具有挑战性的自身免疫性疾病。据估计，10%至17%的狼疮患者在16岁之前发病。儿童SLE似乎比成人有更严重的器官受累情况。在过去十年中，儿童SLE的预后有所改善，但发病率仍然很高。