Gagné E J, Su W P
Department of Dermatology, Mayo Clinic, Rochester, Minnesota 55905.
J Cutan Pathol. 1992 Dec;19(6):469-75. doi: 10.1111/j.1600-0560.1992.tb01599.x.
Immunohistochemical properties were studied in 16 lesions from 11 patients with chordoma involving the skin. There were nine men and two women ranging from 21 to 62 years old (mean, 42.6). The initial tumor was sacrococcygeal in 10 cases and nasopharyngeal in 1 case. Three lesions represented a direct extension from the primary tumor to the skin, and 13 lesions were examples of local recurrences in the skin. Immunohistochemically, all lesions showed positivity for keratin, whereas 14 lesions were positive for vimentin and 12 for protein S-100. Epithelial membrane antigen was positive in four instances and carcinoembryonic antigen was negative in all studies. No significant difference was observed between the immunoprofile of cases of direct extension and those of local recurrences. Overall, the remarkable triple positivity for keratin, vimentin, and protein S-100 was observed in 11 lesions from eight different cases (73%). This study confirmed the utility of immunohistochemistry in the differential diagnosis of chordoma from tumors with similar histologic characteristics encountered in the skin.
对11例累及皮肤的脊索瘤患者的16个病灶进行了免疫组化特性研究。患者中有9名男性和2名女性，年龄在21岁至62岁之间（平均42.6岁）。初始肿瘤位于骶尾部的有10例，位于鼻咽部的有1例。3个病灶代表原发性肿瘤直接蔓延至皮肤，13个病灶为皮肤局部复发的病例。免疫组化结果显示，所有病灶角蛋白均呈阳性，14个病灶波形蛋白呈阳性，12个病灶S-100蛋白呈阳性。上皮膜抗原在4例中呈阳性，癌胚抗原在所有研究中均为阴性。直接蔓延病例和局部复发病例的免疫表型之间未观察到显著差异。总体而言，8例不同病例的11个病灶（73%）观察到角蛋白、波形蛋白和S-100蛋白显著三联阳性。本研究证实了免疫组化在鉴别皮肤中具有相似组织学特征的肿瘤与脊索瘤方面的实用性。
