Suppr超能文献

是否存在发育性帕金森病的亚型?

Is there a subtype of developmental Parkinson's disease?

作者信息

Riederer P

机构信息

Clinic and Polyclinic for Psychiatry and Psychotherapy, Clinical Neurochemistry, Centre of Excellence of the National Parkinson Foundation Miami, University of Wuerzburg, Fuechsleinstrasse 15, 97080 Wuerzburg, Germany.

出版信息

Neurotox Res. 2003;5(1-2):27-34. doi: 10.1007/BF03033370.

Abstract

Evidence accumulates suggesting that environmental factors including viral and risk factors associated with pregnancy and birth-giving, may increase the incidence of hypokinesia/parkinsonism in early life, or PD in later life. Such environmental pre-, peri- or postnatal stress may lead to disturbances in the developing brain and malformations in regions of particular interest and associated with PD. Genetic predisposition to hypoactivity plus environmental effects may lead to reorganization of brain circuitry including changes in monoaminergic and/or EAA systems, leading to a subtype of PD, i.e. genetic, drug induced, viral, developmental and other possible subtypes. The spectrum disorder of PD is going to be further substantiated into various etiopathologically verifyable subgroups.

摘要

越来越多的证据表明,包括病毒在内的环境因素以及与妊娠和分娩相关的风险因素,可能会增加早年运动功能减退/帕金森症的发病率,或晚年帕金森病的发病率。这种环境产前、围产期或产后应激可能会导致发育中的大脑出现紊乱,并在特别感兴趣且与帕金森病相关的区域出现畸形。活动减退的遗传易感性加上环境影响可能会导致大脑回路的重组,包括单胺能和/或兴奋性氨基酸系统的变化,从而导致帕金森病的一种亚型,即遗传型、药物诱导型、病毒型、发育型和其他可能的亚型。帕金森病的谱系障碍将进一步细分为各种病因病理可验证的亚组。

相似文献

2
Comparison of two motor subtype classifications in de novo Parkinson's disease.两种新发帕金森病运动亚型分类的比较。
Parkinsonism Relat Disord. 2018 Sep;54:74-78. doi: 10.1016/j.parkreldis.2018.04.021. Epub 2018 Apr 18.
5
Re-Emergent Kinetic Tremor in Parkinson's Disease.帕金森病中的再发性运动性震颤
Tremor Other Hyperkinet Mov (N Y). 2019 Jul 5;9. doi: 10.7916/tohm.v0.660. eCollection 2019.
9
[Gender dimorphism in Parkinson's disease].
Zh Nevrol Psikhiatr Im S S Korsakova. 2003;103(12):10-4.
10
Motor complications in Parkinson's disease.帕金森病的运动并发症。
Int J Neurosci. 2011;121 Suppl 2:37-44. doi: 10.3109/00207454.2011.620198.

本文引用的文献

4
Apoptosis in the basal ganglia of the developing human nervous system.
Acta Neuropathol. 2001 Feb;101(2):92-100. doi: 10.1007/s004010000252.
9
Developmental cell death in dopaminergic neurons of the substantia nigra of mice.小鼠黑质多巴胺能神经元中的发育性细胞死亡。
J Comp Neurol. 2000 Aug 28;424(3):476-88. doi: 10.1002/1096-9861(20000828)424:3<476::aid-cne6>3.0.co;2-0.

文献检索

告别复杂PubMed语法,用中文像聊天一样搜索,搜遍4000万医学文献。AI智能推荐,让科研检索更轻松。

立即免费搜索

文件翻译

保留排版,准确专业,支持PDF/Word/PPT等文件格式,支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述,25分钟生成高质量综述,智能提取关键信息,辅助科研写作。

立即免费体验