Gamboa Domínguez A, Pita Ramírez L, Hurtado Monroy R, Angeles-Angeles A
Departamento de Patología, Instituto Nacional de la Nutrición Salvador Zubirán, D.F., México.
Rev Invest Clin. 1992 Jul-Sep;44(3):393-8.
In 18 years of experience in the use of combined chemotherapy in Hodgkin's disease at the Instituto Nacional de la Nutrición Salvador Zubirán, the first case of non-Hodgkin's lymphoma secondary to Hodgkin's disease was identified. The patient was a 23 year old male who initially developed a nodular sclerosis type of Hodgkin's disease. Three years later, the biopsies showed lymphocyte predominance type of Hodgkin's disease. Finally, one year later, the patient developed a diffuse small cleaved cell lymphoma. Non-Hodgkin's lymphoma occurring in patients treated with combined chemotherapy and radiotherapy after Hodgkin's disease is a rare complication. We believe that the genesis of a second neoplasm in these cases may be due to both disturbances in the cellular immunity intrinsic to Hodgkin's disease and the treatment with combined chemotherapy and radiotherapy.
在萨尔瓦多·苏比拉án国家营养研究所使用联合化疗治疗霍奇金病的18年经验中，首次发现了继发于霍奇金病的非霍奇金淋巴瘤病例。该患者为一名23岁男性，最初患结节硬化型霍奇金病。三年后，活检显示为淋巴细胞为主型霍奇金病。最后，一年后，该患者发展为弥漫性小裂细胞淋巴瘤。霍奇金病患者接受联合化疗和放疗后发生非霍奇金淋巴瘤是一种罕见的并发症。我们认为，这些病例中第二种肿瘤的发生可能是由于霍奇金病固有的细胞免疫紊乱以及联合化疗和放疗的治疗。
