Saito H, Ohtsubo T, Fujieda S, Tanigawa N
Department of Otolaryngology, Fukui Medical School, Japan.
Eur Arch Otorhinolaryngol. 1992;249(7):400-3. doi: 10.1007/BF00192262.
The chemosensitivity of various head and neck cancers was investigated with the 5-day rapid thymidine incorporation assay in soft agar culture. The evaluability rate was 56%. Head and neck cancers were sensitive in vitro, in decreasing order, to peplomycin, cisplatin, bleomycin, 5-fluorouracil, mitomycin C, and doxorubicin. Primary tumors and neck metastases exhibited the same sensitivity, with 21% of all specimens tested responding. In vitro chemosensitivities were similar among patients younger than 69 years of age and those older than 70. The predictive accuracy for sensitivity tested prospectively in five cases was 80% and that for resistance in four was 75%.
采用软琼脂培养中的5天快速胸苷掺入试验，对各种头颈癌的化学敏感性进行了研究。可评估率为56%。头颈癌在体外对培普利霉素、顺铂、博来霉素、5-氟尿嘧啶、丝裂霉素C和阿霉素的敏感性依次降低。原发性肿瘤和颈部转移瘤表现出相同的敏感性，所有检测标本中有21%有反应。69岁以下患者和70岁以上患者的体外化学敏感性相似。对5例患者进行前瞻性检测的敏感性预测准确率为80%，对4例患者进行耐药性预测的准确率为75%。
