Ransom D T, Ritland S R, Kimmel D W, Moertel C A, Dahl R J, Scheithauer B W, Kelly P J, Jenkins R B
Section of Laboratory Genetics, Mayo Clinic and Foundation, Rochester, Minnesota.
Genes Chromosomes Cancer. 1992 Nov;5(4):348-56. doi: 10.1002/gcc.2870050411.
Cytogenetic and/or loss of heterozygosity studies were performed on 13 ependymomas, 11 pilocytic astrocytomas, and 18 oligodendrogliomas. Loss of chromosome 22 was the most frequent genetic abnormality among the ependymomas. We found no consistent genetic abnormality in pilocytic astrocytomas. The most common genetic abnormality in oligodendrogliomas was loss of a portion of chromosome 19. Each informative oligodendroglioma had loss of alleles mapped to the long arm (q) of chromosome 19. One oligodendroglioma had an apparent homozygous deletion of the D19S8 locus. Our results, when combined with those in the literature, indicate that chromosomes 9, 11, and 22 may harbor genes important for the pathogenesis of ependymomas and that 19q probably harbors a gene important for the pathogenesis of oligodendrogliomas.
对13例室管膜瘤、11例毛细胞型星形细胞瘤和18例少突胶质细胞瘤进行了细胞遗传学和/或杂合性缺失研究。22号染色体缺失是室管膜瘤中最常见的基因异常。我们在毛细胞型星形细胞瘤中未发现一致的基因异常。少突胶质细胞瘤中最常见的基因异常是19号染色体部分缺失。每例有信息的少突胶质细胞瘤都有位于19号染色体长臂（q）上的等位基因缺失。1例少突胶质细胞瘤出现了D19S8位点明显的纯合缺失。我们的结果与文献中的结果相结合，表明9号、11号和22号染色体可能含有对室管膜瘤发病机制重要的基因，而19q可能含有对少突胶质细胞瘤发病机制重要的基因。
