Hutchings Anne, Thomas Judith M
Department of Surgery, University of Alabama at Birmingham, Birmingham, AL 35294, USA.
Curr Opin Investig Drugs. 2003 May;4(5):530-5.
The immunosuppressive regimens currently in use have been responsible for major improvements in transplanted organ acceptance, but long-term survival can be compromised by drug toxicity and/or chronic immune deficiency. The ultimate goal for transplantation is tolerance, defined as durable, donor-specific allograft acceptance in the absence of long-term immunosuppression. This review describes current experimental strategies for tolerance induction in primate models that are poised for clinical application.
目前使用的免疫抑制方案已使移植器官的接受情况有了重大改善，但长期存活可能会受到药物毒性和/或慢性免疫缺陷的影响。移植的最终目标是实现免疫耐受，即指在无长期免疫抑制的情况下持久、特异性地接受供体移植物。这篇综述描述了灵长类动物模型中目前诱导免疫耐受的实验策略，这些策略已准备好应用于临床。
