Ulanova Marina, Puttagunta Lakshmi, Kim Moo-Kyung, Schreiber Alan D, Befus A Dean
Department of Medicine, University of Alberta, Edmonton, Alberta, T6G 2S2, Canada.
Curr Opin Investig Drugs. 2003 May;4(5):552-5.
The non-receptor protein tyrosine kinase Syk plays a critical role in intracellular signaling in the inflammatory response. Specific inhibition of Syk using aerosolized antisense delivered in liposome complexes can significantly decrease inflammatory responses in the airways in experimental animal models. Thus, it is tempting to examine local application of Syk antisense for the treatment of inflammatory respiratory diseases as asthma. However, evidence that Syk kinase is more widely distributed in different cell types than previously recognized, as well as its potential involvement in cell differentiation, adhesion and proliferation, dictates that the precise cellular targets for antisense therapy in the airways must be determined. Given the critical role of Syk in intracellular signaling in inflammatory responses, Syk antisense oligonucleotides (InKine Pharmaceutical Co Inc) may prove useful as anti-inflammatory therapy in disorders such as asthma.
非受体蛋白酪氨酸激酶Syk在炎症反应的细胞内信号传导中起关键作用。在实验动物模型中，使用脂质体复合物递送的雾化反义寡核苷酸对Syk进行特异性抑制，可显著降低气道中的炎症反应。因此，很有必要研究Syk反义寡核苷酸的局部应用，用于治疗如哮喘等炎症性呼吸道疾病。然而，有证据表明，Syk激酶在不同细胞类型中的分布比之前认为的更为广泛，以及其可能参与细胞分化、黏附和增殖，这表明必须确定气道中反义疗法的精确细胞靶点。鉴于Syk在炎症反应的细胞内信号传导中起关键作用，Syk反义寡核苷酸（InKine制药公司）可能被证明可作为哮喘等疾病的抗炎疗法。
