Tremblay Guy M, Janelle Marie France, Bourbonnais Yves
Unité de recherche, Hôpital Laval, Institut universitaire de cardiologie et de pneumologie, l'Université Laval, 2725 chemin Sainte-Foy, Sainte-Foy, G1V 4G5, Canada.
Curr Opin Investig Drugs. 2003 May;4(5):556-65.
Neutrophil elastase is a protease that is involved in the tissue destruction and inflammation that characterize numerous diseases, including hereditary emphysema, chronic obstructive pulmonary disease, cystic fibrosis, adult respiratory distress syndrome, ischemic-reperfusion injury and rheumatoid arthritis. Thus, elastase has been the object of extensive research to develop potent inhibitors that target its destructive and pro-inflammatory action. This review focuses on the anti-inflammatory activity of inhibitors that are currently, or were until recently in development, including purified or recombinantly produced endogenous inhibitors, genetically modified recombinant protein inhibitors and synthetic small-molecule inhibitors.
中性粒细胞弹性蛋白酶是一种蛋白酶，参与多种疾病所特有的组织破坏和炎症过程，这些疾病包括遗传性肺气肿、慢性阻塞性肺疾病、囊性纤维化、成人呼吸窘迫综合征、缺血再灌注损伤和类风湿性关节炎。因此，弹性蛋白酶一直是广泛研究的对象，旨在开发针对其破坏作用和促炎作用的强效抑制剂。本综述重点关注目前正在研发或直到最近仍在研发的抑制剂的抗炎活性，包括纯化的或重组产生的内源性抑制剂、基因改造的重组蛋白抑制剂和合成小分子抑制剂。
