Panagiotidis G, Alm P, Lundquist I
Department of Pharmacology, University of Lund, Sweden.
Eur J Pharmacol. 1992 Dec 15;229(2-3):277-8. doi: 10.1016/0014-2999(92)90568-o.
NG-Nitro-L-arginine, an inhibitor of nitric oxide (NO) synthase, markedly (+50%) increased the L-arginine-induced insulin release from isolated mouse islets but did not itself influence insulin secretion. An abundance of mouse islet cells were positively stained for the enzyme NADPH diaphorase, which reportedly is a marker for NO synthase. The data suggest that the NO synthase activity in mouse islet tissue may inhibit insulin secreting processes and that L-arginine has a dual action on insulin release.
NG-硝基-L-精氨酸是一氧化氮（NO）合酶的抑制剂，可显著（增加50%）增强L-精氨酸诱导的分离小鼠胰岛的胰岛素释放，但它本身并不影响胰岛素分泌。大量小鼠胰岛细胞对酶NADPH黄递酶呈阳性染色，据报道该酶是NO合酶的标志物。数据表明，小鼠胰岛组织中的NO合酶活性可能抑制胰岛素分泌过程，且L-精氨酸对胰岛素释放具有双重作用。
