帕金森病的治疗与大鼠中自由基诱导的神经毒性——体内伏安法研究
Therapy of Morbus Parkinson and radical-induced neurotoxicity in the rat--in vivo voltammetric studies.
作者信息
Wesemann W
机构信息
Abteilung Neurochemie, Philipps-Universität, Marburg, Federal Republic of Germany.
出版信息
J Neural Transm Suppl. 1992;38:45-53.
PMID:1283403
Abstract
In vivo pulse voltammetry was used to study the effect of anti-parkinsonian drugs and of neurotoxins in rat striatum. It could be demonstrated that besides the well-known changes of total dopamine (DA) concentrations the applied drugs affected also the extraneuronal DA metabolism in the living rat. In addition, neurotoxin-treated rats can be used as a model to study some aspects of the Parkinson syndrome.
摘要
采用体内脉冲伏安法研究抗帕金森病药物和神经毒素对大鼠纹状体的影响。结果表明，除了众所周知的总多巴胺（DA）浓度变化外，所应用的药物还影响了活鼠体内神经元外DA的代谢。此外，经神经毒素处理的大鼠可作为研究帕金森综合征某些方面的模型。
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