关于人丁酰胆碱酯酶形成的异源复合物的研究。

Studies on a heterologous complex formed by human butyrylcholinesterase.

作者信息

Souza R L R, Furtado L, Diniz A C P, Silva A C D, Kaiss J, Petzl-Erler M L, Chautard-Freire-Maia E A

机构信息

Department of Genetics, Federal University of Paraná, PO Box 19071, 81531-990 Curitiba, PR, Brazil.

出版信息

Biochem Genet. 2003 Jun;41(5-6):141-50. doi: 10.1023/a:1023373526230.

DOI:10.1023/a:1023373526230

PMID:12834044

Abstract

An electrophoretic band with butyrylcholinesterase activity was detected in 71 CHE2 C5+ and 378 CHE2 C5- individuals and was named C4/5 in view of its similar mobility to either C4 or C5, depending on the pH of the agar gel used. The present data suggest that C4/5 is a heterologous complex of butyrylcholinesterase. Although the C4/5 band may have the same mobility as C5, depending on the conditions of electrophoresis, our hypothesis is that these two bands result from the association of BChE with different molecules.

摘要

在71名CHE2 C5+个体和378名CHE2 C5-个体中检测到一条具有丁酰胆碱酯酶活性的电泳带，鉴于其迁移率与C4或C5相似（取决于所用琼脂凝胶的pH值），将其命名为C4/5。目前的数据表明，C4/5是丁酰胆碱酯酶的异源复合物。尽管根据电泳条件，C4/5带可能与C5具有相同的迁移率，但我们的假设是，这两条带是由丁酰胆碱酯酶与不同分子的结合产生的。