一氧化氮合酶抑制剂对大鼠胃碱性分泌的影响。
Effects of nitric oxide synthase inhibitors on gastric alkaline secretion in rats.
作者信息
Takeuchi K, Ohuchi T, Miyake H, Sugawara H, Okabe S
机构信息
Department of Applied Pharmacology, Kyoto Pharmaceutical University, Japan.
出版信息
Jpn J Pharmacol. 1992 Nov;60(3):303-5. doi: 10.1254/jjp.60.303.
The effects of NG-nitro-L-arginine methyl ester (L-NAME), the nitric oxide (NO) synthase inhibitor, on gastric HCO3- secretion were examined in anesthetized rats. Intravenous administration of L-NAME (1, 2.5, 5 mg/kg) increased HCO3- secretion in a dose-related manner. This effect of L-NAME was mimicked by NG-mono-methyl-L-arginine (50 mg/kg, i.v.) and was antagonized significantly by concurrent administration of L-arginine but not D-arginine (200 mg/kg, i.v.). These results indicate that gastric HCO3- secretion is stimulated by inhibition of NO biosynthesis.
在麻醉大鼠中研究了一氧化氮（NO）合酶抑制剂NG-硝基-L-精氨酸甲酯（L-NAME）对胃HCO₃⁻分泌的影响。静脉注射L-NAME（1、2.5、5mg/kg）以剂量相关的方式增加了HCO₃⁻分泌。NG-单甲基-L-精氨酸（50mg/kg，静脉注射）模拟了L-NAME的这种作用，同时给予L-精氨酸（200mg/kg，静脉注射）可显著拮抗L-NAME的作用，但给予D-精氨酸则无此作用。这些结果表明，抑制NO生物合成可刺激胃HCO₃⁻分泌。
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