Chappel L R
Avian Dis. 1975 Oct-Dec;19(4):679-82.
Ten-day-old White Leghorn cockerels were inoculated per cloaca with 500,000 culture forms of the HmL1 strain of Histomonas meleagridis. Birds dying on the 6th and 7th days and birds necropsied 7 days postinoculation had prominent cecal and liver lesions indicative of severe histomoniasis. Dose responses were obtained with three 1,2-disubstituted 5-nitroimidazoles blended into the feed at various concentrations, demonstrating the utility of this virulent strain in chemotherapy studies.
将500,000个火鸡组织滴虫HmL1菌株的培养形态通过泄殖腔接种给10日龄的白来航公鸡。在接种后第6天和第7天死亡的鸡以及接种7天后进行剖检的鸡，盲肠和肝脏出现明显病变，表明患有严重的组织滴虫病。将三种1,2 - 二取代5 - 硝基咪唑以不同浓度混入饲料中获得了剂量反应，证明了这种强毒株在化疗研究中的实用性。
