McCreadie Robin G, Thara Rangaswamy, Srinivasan Tirupati N, Padmavathi Ramachandra
Department of Clinical Research, Crichton Royal Hospital, Dumfries, UK.
Br J Psychiatry. 2003 Jul;183:45-9. doi: 10.1192/bjp.183.1.45.
We have suggested recently that there may be a subgroup of schizophrenia, namely schizophrenia with dyskinesia and striatal pathology. Might movement disorders be more common in relatives of those with schizophrenia and dyskinesia than in relatives of those without dyskinesia? Aims To determine the prevalence of abnormal movements in first-degree relatives of people with schizophrenia who themselves do or do not have abnormal movements.
Chronically ill, never-treated people with schizophrenia in south India (n=70) and their first-degree relatives (n=181) were examined for dyskinesia using the Abnormal Involuntary Movements Scale (AIMS) and for parkinsonism by the Simpson and Angus scale.
Of all relatives, 25 (14%) had dyskinetic movements in at least one body area and 6 (3%) had parkinsonism. Siblings of people with schizophrenia and dyskinesia, compared with siblings of people without dyskinesia, had a higher total AIMS score and more had mild dyskinetic movements in at least one area (5/15 v. 3/34, P=0.04). There were no between-group differences in parkinsonism.
Dyskinesia but not parkinsonism is more common in siblings of people with schizophrenia who have the corresponding movement disorder.
我们最近提出，可能存在精神分裂症的一个亚组，即伴有运动障碍和纹状体病变的精神分裂症。与无运动障碍者的亲属相比，伴有运动障碍的精神分裂症患者的亲属中运动障碍是否更常见？目的确定有或无异常运动的精神分裂症患者的一级亲属中异常运动的患病率。
使用异常不自主运动量表（AIMS）对印度南部的慢性未治疗精神分裂症患者（n = 70）及其一级亲属（n = 181）进行运动障碍检查，并使用辛普森和安格斯量表检查帕金森症。
在所有亲属中，25人（14%）至少有一个身体部位出现运动障碍性运动，6人（3%）患有帕金森症。与无运动障碍者的兄弟姐妹相比，伴有运动障碍的精神分裂症患者的兄弟姐妹的AIMS总分更高，且更多人至少有一个部位出现轻度运动障碍性运动（5/15对3/34，P = 0.04）。帕金森症在两组之间无差异。
在患有相应运动障碍的精神分裂症患者的兄弟姐妹中，运动障碍比帕金森症更常见。
