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Oral Oncol. 2002 Jan;38(1):23-9. doi: 10.1016/s1368-8375(01)00008-2.
2
Mapping of the candidate tumor suppressor genes' loci on human chromosome 3 in head and neck squamous cell carcinoma of an Indian patient population.印度患者群体头颈部鳞状细胞癌中候选肿瘤抑制基因座在人类3号染色体上的定位。
Oral Oncol. 2002 Jan;38(1):6-15. doi: 10.1016/s1368-8375(00)00131-7.
3
Accumulative increase of loss of heterozygosity from leukoplakia to foci of early cancerization in leukoplakia of the oral cavity.口腔白斑中从白斑到早期癌变病灶杂合性缺失的累积增加。
Cancer. 2001 Nov 1;92(9):2349-56. doi: 10.1002/1097-0142(20011101)92:9<2349::aid-cncr1582>3.0.co;2-i.
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Chromosomal alterations in squamous cell carcinomas of the head and neck: window to the biology of disease.头颈部鳞状细胞癌中的染色体改变：疾病生物学之窗
Head Neck. 2001 Mar;23(3):238-53. doi: 10.1002/1097-0347(200103)23:3<238::aid-hed1025>3.0.co;2-h.
5
Loss of heterozygosity at 11q23.3 in vasculoinvasive and metastatic squamous cell carcinoma of the cervix.宫颈血管浸润性和转移性鳞状细胞癌中11q23.3处杂合性缺失
Hum Pathol. 2001 May;32(5):475-8. doi: 10.1053/hupa.2001.24317.
6
Microsatellite instability in squamous cell carcinoma of head and neck from the Indian patient population.印度患者群体中头颈部鳞状细胞癌的微卫星不稳定性
Int J Cancer. 2001 May 15;92(4):555-61. doi: 10.1002/ijc.1233.
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Mechanisms underlying losses of heterozygosity in human colorectal cancers.人类结直肠癌杂合性缺失的潜在机制。
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Spectral karyotyping suggests additional subsets of colorectal cancers characterized by pattern of chromosome rearrangement.光谱核型分析表明，结直肠癌存在以染色体重排模式为特征的其他亚组。
Proc Natl Acad Sci U S A. 2001 Feb 27;98(5):2538-43. doi: 10.1073/pnas.041603298. Epub 2001 Feb 20.
9
Analysis of genetic alterations in primary nasopharyngeal carcinoma by comparative genomic hybridization.通过比较基因组杂交分析原发性鼻咽癌的基因改变
Genes Chromosomes Cancer. 2001 Mar;30(3):254-60. doi: 10.1002/1098-2264(2000)9999:9999<::aid-gcc1086>3.0.co;2-d.
10
Identification of a 6-cM minimal deletion at 11q23.1-23.2 and exclusion of PPP2R1B gene as a deletion target in cervical cancer.在宫颈癌中鉴定出11q23.1 - 23.2区域6厘摩的最小缺失，并排除PPP2R1B基因作为缺失靶点。
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印度患者群体中头颈部鳞状细胞癌11号染色体的等位基因失衡

Allelic imbalance at chromosome 11 in head and neck squamous cell carcinoma in an Indian patient population.

作者信息

Mondal G, Tripathi A, Bhattacharya N, Sikdar N, Roy A, Sengupta A, Roy B, Panda C K, Roychoudhury S

机构信息

Human Genetics and Genomics Division, Indian Institute of Chemical Biology, Kolkata 700 032, India.

出版信息

J Clin Pathol. 2003 Jul;56(7):512-8. doi: 10.1136/jcp.56.7.512.

DOI:10.1136/jcp.56.7.512
PMID:12835296
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC1769990/
Abstract

BACKGROUND

Genetic instability of chromosome 11 is a frequent event in many solid tumours, including head and neck squamous cell carcinoma (HNSCC).

AIMS

To perform allelic imbalance analysis of cytogenetically mapped altered regions of human chromosome 11 in patients with HNSCC from eastern India.

METHODS

Genomic alterations were investigated using highly polymorphic microsatellite markers in both HNSCC and leukoplakia tissues.

RESULTS

Microsatellite markers D11S1758 from 11p13-15 and D11S925 from 11q23.3-24 had the highest frequency (38% and 32%, respectively) of loss of heterozygosity among all the markers analysed. Allelic loss at the marker D11S925 was seen in both leukoplakia and in all stages of HNSCC tumour tissues suggesting that it is an early event in HNSCC tumorigenesis. Microsatellite size alteration was also found to be high (> 20%) in several markers. In leukoplakia samples microsatellite instability was seen at a higher frequency than loss of the allele, indicating such alterations might initiate the process of tumorigenesis in HNSCC.

CONCLUSIONS

The high rate of chromosomal alterations at 11q21-24 in HNSCC suggests the presence of a putative tumour suppressor gene in this region.

摘要

背景

11号染色体的基因不稳定在许多实体瘤中是常见事件，包括头颈部鳞状细胞癌（HNSCC）。

目的

对来自印度东部的HNSCC患者的人类11号染色体细胞遗传学定位改变区域进行等位基因失衡分析。

方法

使用高度多态性微卫星标记对HNSCC和白斑组织中的基因组改变进行研究。

结果

在所有分析的标记中，来自11p13 - 15的微卫星标记D11S1758和来自11q23.3 - 24的D11S925杂合性缺失频率最高（分别为38%和32%）。在白斑和HNSCC肿瘤组织的所有阶段均可见标记D11S925的等位基因缺失，提示其为HNSCC肿瘤发生的早期事件。还发现几个标记的微卫星大小改变也很高（>20%）。在白斑样本中，微卫星不稳定性的出现频率高于等位基因缺失，表明此类改变可能启动了HNSCC的肿瘤发生过程。

结论

HNSCC中11q21 - 24的染色体改变率高，提示该区域存在一个假定的肿瘤抑制基因。