Rawlins Emma L, White Neil M, Jarman Andrew P
Wellcome Trust Centre for Cell Biology, Institute of Cell and Molecular Biology, University of Edinburgh, King's Buildings, Edinburgh EH9 3JR, Scotland, UK.
Development. 2003 Aug;130(16):3715-24. doi: 10.1242/dev.00602.
EGF receptor signalling plays diverse inductive roles during development. To achieve this, its activity must be carefully regulated in a variety of ways to control the time, pattern, intensity and duration of signalling. We show that the cell surface protein Echinoid is required to moderate Egfr signalling during R8 photoreceptor selection by the proneural gene atonal during Drosophila eye development. In echinoid mutants, Egfr signalling is increased during R8 formation, and this causes isolated R8 cells to be replaced by groups of two or three cells. This mutant phenotype resembles the normal inductive function of Egfr in other developmental contexts, particularly during atonal-controlled neural recruitment of chordotonal sense organ precursors. We suggest that echinoid acts to prevent a similar inductive outcome of Egfr signalling during R8 selection.
表皮生长因子（EGF）受体信号传导在发育过程中发挥着多种诱导作用。为实现这一点，其活性必须通过多种方式进行精细调节，以控制信号传导的时间、模式、强度和持续时间。我们发现，在果蝇眼睛发育过程中，原神经基因无调蛋白（atonal）选择R8光感受器时，细胞表面蛋白海胆蛋白（Echinoid）是调节表皮生长因子受体（Egfr）信号传导所必需的。在海胆蛋白突变体中，R8形成过程中Egfr信号传导增强，这导致单个R8细胞被两三个细胞组成的细胞团所取代。这种突变表型类似于Egfr在其他发育环境中的正常诱导功能，特别是在无调蛋白控制的弦音感受器前体神经募集过程中。我们认为，海胆蛋白在R8选择过程中起到了防止Egfr信号传导产生类似诱导结果的作用。
