肝素结合表皮生长因子样生长因子在银屑病表皮中的变化及其意义

Alteration and significance of heparin-binding epidermal-growth-factor-like growth factor in psoriatic epidermis.

作者信息

Zheng Yan, Peng Zhenhui, Wang Yili, Tan Shengshun, Xi Yanping, Wang Guorong

机构信息

Institute of Immunopathology, Xi'an Jiaotong University, Xi'an, Shaanxi, PR China.

出版信息

Dermatology. 2003;207(1):22-7. doi: 10.1159/000070936.

DOI:10.1159/000070936

PMID:12835543

Abstract

BACKGROUND

Heparin-binding epidermal-growth-factor-like growth factor (HB-EGF) has proved to be a mitogen of keratinocytes, which may be involved in the pathogenesis of inflammatory diseases, but its mechanism in psoriasis remains unknown.

OBJECTIVE

To investigate the alteration of HB-EGF in the epidermis of active psoriasis vulgaris.

METHODS

The expression of HB-EGF in normal skin tissues, uninvolved tissues and psoriatic lesions was detected by in situ hybridization and immunohistochemistry.

RESULTS

HB-EGF mRNA and protein were located in the basal layer of normal epidermis (10/10, 100.00%), with nearly no expression in the suprabasal layers (1/10, 10.00%); the expression of HB-EGF was located not only in the basal layer (21/21, 100.00%), but was also seen as focal overexpression in the suprabasal layers of uninvolved epidermis (20/21, 95.24%) and the marginal part of psoriatic lesions (18/21, 85.71%), while nearly no expression of HB-EGF was found in the central part of psoriatic lesions (1/21, 4.76%).

CONCLUSION

HB-EGF may play an important role in the early pathogenesis of psoriasis.

摘要

背景

肝素结合表皮生长因子样生长因子（HB-EGF）已被证明是角质形成细胞的有丝分裂原，可能参与炎症性疾病的发病机制，但其在银屑病中的作用机制尚不清楚。

目的

探讨寻常型银屑病活动期表皮中HB-EGF的变化。

方法

采用原位杂交和免疫组化方法检测正常皮肤组织、非皮损组织及银屑病皮损中HB-EGF的表达。

结果

HB-EGF mRNA和蛋白位于正常表皮基底层（10/10，100.00%），基底层以上几乎无表达（1/10，10.00%）；HB-EGF不仅表达于非皮损表皮基底层（21/21，100.00%），在非皮损表皮基底层以上（20/21，95.24%）及银屑病皮损边缘部分（18/21，85.71%）呈局灶性过表达，而在银屑病皮损中央部分几乎无表达（1/21，4.76%）。