Dummer Reinhard, Ivanova Katya, Scheidegger E Paul, Burg Günter
Department of Dermatology, University Hospital, Zurich, Switzerland.
Dermatology. 2003;207(1):93-5. doi: 10.1159/000070956.
Polymorphous light eruption (PLE) is an idiopathic eruption induced by ultraviolet (UV) radiation (UVR).
Evaluation of the clinical aspects, diagnostic criteria of PLE in a major Swiss referral center.
25 patients with PLE were tested with a standardized protocol for the assessment of photodermatoses.
25 patients (22 women vs. 3 men) were identified. Papular and papular-vesicular eruptions were the most common clinical presentations. 6 of 25 patients had a reduced minimal erythema dose (MED) for UVA and 8 of 25 patients had a reduced MED for UVB. Photoprovocation was positive in 11 of 20 patients for UVA and 7 of 20 patients for UVB. Photohardening with narrow-band UVB was successful in 8 of 10 patients. Combined UVA/UVB therapy had a satisfactory effect in 10 of 15 patients. Narrow-band UVB therapy was still successful after ineffective UVA/UVB therapy.
The MED was of no value for the diagnosis of PLE. The typical lesions were reproduced by UVA and UVB photoprovocation. We recommend photohardening with narrow-band UVB (311 nm).
多形性日光疹（PLE）是一种由紫外线（UV）辐射诱发的特发性皮疹。
在瑞士一家主要的转诊中心评估PLE的临床特征及诊断标准。
采用标准化方案对25例PLE患者进行光皮肤病评估测试。
共确诊25例患者（22例女性，3例男性）。丘疹及丘疹水疱型皮疹是最常见的临床表现。25例患者中有6例UVA最小红斑量（MED）降低，25例患者中有8例UVB的MED降低。20例患者中11例UVA光激发试验阳性，20例患者中7例UVB光激发试验阳性。10例患者中有8例采用窄谱UVB光致硬化治疗成功。15例患者中有10例采用UVA/UVB联合治疗效果满意。在UVA/UVB治疗无效后，窄谱UVB治疗仍取得成功。
MED对PLE的诊断无价值。UVA和UVB光激发试验可再现典型皮损。我们推荐采用窄谱UVB（311nm）进行光致硬化治疗。
