Katoh K, Tohyama M, Noguchi K, Senba E
Department of Anatomy, Osaka University Medical School, Japan.
Brain Res. 1992 Dec 18;599(1):153-7. doi: 10.1016/0006-8993(92)90864-6.
Axonal flow of motoneurons was blocked in the sciatic nerve by the application of vinblastine at a low concentration (100 microM) not considered likely to cause axonal degeneration. The number of motoneurons expressing alpha-calcitonin gene-related peptide (CGRP) mRNA was significantly increased by vinblastine application, while the expression of beta-CGRP mRNA was not influenced. These findings suggest that the synthesis of these two peptides is differentially regulated and that alpha-CGRP mRNA is possibly down-regulated by unknown factor(s) which normally undergo retrograde transport from the periphery.
通过应用低浓度（100微摩尔）的长春花碱阻断坐骨神经中运动神经元的轴突运输，该浓度被认为不太可能导致轴突退变。应用长春花碱后，表达α-降钙素基因相关肽（CGRP）mRNA的运动神经元数量显著增加，而β-CGRP mRNA的表达未受影响。这些发现表明，这两种肽的合成受到不同的调节，并且α-CGRP mRNA可能被通常从外周进行逆行运输的未知因子下调。
