Rao Jasti S
Program of Cancer Biology, Department of Neurosurgery, University of Illinois College of Medicine-Peoria, 1 Illini Drive, Peoria, Illinois 61656, USA.
Nat Rev Cancer. 2003 Jul;3(7):489-501. doi: 10.1038/nrc1121.
The invasive nature of brain-tumour cells makes an important contribution to the ineffectiveness of current treatment modalities, as the remaining tumour cells inevitably infiltrate the surrounding normal brain tissue, which leads to tumour recurrence. Such local invasion remains an important cause of mortality and underscores the need to understand in more detail the mechanisms of tumour invasiveness. Several proteases influence the malignant characteristics of gliomas--could their inhibition prove to be a useful therapeutic strategy?
脑肿瘤细胞的侵袭性是导致当前治疗方式效果不佳的一个重要因素，因为残留的肿瘤细胞不可避免地会浸润周围正常脑组织，进而导致肿瘤复发。这种局部侵袭仍然是一个重要的致死原因，凸显了更详细了解肿瘤侵袭机制的必要性。几种蛋白酶会影响胶质瘤的恶性特征——抑制这些蛋白酶能否成为一种有效的治疗策略呢？
