Olszewska Ewa, Wagner Mathias, Bernal-Sprekelsen Manuel, Ebmeyer Jörg, Dazert Stefan, Hildmann Henning, Sudhoff Holger
Department of Otorhinolaryngology and Head and Neck Surgery, Medical Academy, Bialystok, Poland.
Eur Arch Otorhinolaryngol. 2004 Jan;261(1):6-24. doi: 10.1007/s00405-003-0623-x. Epub 2003 Jun 27.
Cholesteatoma is a destructive lesion of the temporal bone that gradually expands and causes complications by erosion of the adjacent bony structures. Bone resorption can result in destruction of the ossicular chain and otic capsule with consecutive hearing loss, vestibular dysfunction, facial paralysis and intracranial complications. Surgery is the only treatment of choice. The etiopathogenesis of cholesteatoma, however, is still controversial. This review was designed to understand the reasons for these disparities and to reduce or eliminate them. Future studies focused on developmental, epidemiological, hormonal and genetic factors as well as on treatment are likely to contribute to further understanding of cholesteatoma pathogenesis.
胆脂瘤是颞骨的一种破坏性病变，其会逐渐扩大，并通过侵蚀相邻的骨质结构而引发并发症。骨质吸收可导致听骨链和耳囊破坏，继而造成听力丧失、前庭功能障碍、面瘫及颅内并发症。手术是唯一的治疗选择。然而，胆脂瘤的病因发病机制仍存在争议。本综述旨在了解这些差异产生的原因并减少或消除它们。未来聚焦于发育、流行病学、激素和遗传因素以及治疗方面的研究，可能有助于进一步理解胆脂瘤的发病机制。
