Charvet Céline, Deckert Marcel
Inserm U.343, Interactions cellulaires en immunologie et immunopathologie, Hôpital de l'Archet, Route de Saint-Antoine de Ginestière, BP 3079, 06202 Nice, France.
Med Sci (Paris). 2003 Feb;19(2):217-22. doi: 10.1051/medsci/2003192217.
Guanine exchange factors (GEF) of the Vav family are critical activators of Rho GTPases, which control actin cytoskeletal reorganization and gene transcription. Among all GEFs identified, Vav proteins are the only GEFs regulated by tyrosine phosphorylation. Moreover, their structure contains several protein-protein or protein-lipid interaction domains. These domains are involved in the formation of multimolecular signalling complexes, highlighting the adaptor role of Vav proteins. The unique combination of these properties makes Vav proteins privileged integrators of multiple signalling pathways in a broad range of tissues and cells. Lymphocyte function during inflammatory and immune responses requires a dynamic remodeling of cellular architecture. Thus, it is not surprising that Vav proteins have been found to play a central role in the regulation of physiologic and pathologic lymphocyte responses.
Vav家族的鸟嘌呤核苷酸交换因子（GEF）是Rho GTP酶的关键激活剂，Rho GTP酶控制肌动蛋白细胞骨架重组和基因转录。在所有已鉴定的GEF中，Vav蛋白是唯一受酪氨酸磷酸化调节的GEF。此外，它们的结构包含几个蛋白质-蛋白质或蛋白质-脂质相互作用结构域。这些结构域参与多分子信号复合物的形成，突出了Vav蛋白的衔接子作用。这些特性的独特组合使Vav蛋白成为广泛组织和细胞中多种信号通路的特权整合者。炎症和免疫反应期间的淋巴细胞功能需要细胞结构的动态重塑。因此，发现Vav蛋白在生理性和病理性淋巴细胞反应的调节中起核心作用也就不足为奇了。
