Petrogiannopoulos C, Kalogeropoulos S, Latsios G S, Hartzoulakis G, Kalogeropoulos G, Zaharof A
Hellenic Red Cross Hospital, Athens, Greece.
Int J Clin Pharmacol Res. 2002;22(3-4):85-8.
In the present study, we investigated the effects of a 6-month treatment with orlistat on body weight and lipid profile in 27 overweight women (mean body mass index [BMI]: 27.5 kg/m2; median age: 38.4 years) with mild hypercholesterolemia (total cholesterol: 225 mg/dl; low-density lipoprotein cholesterol [LDL-C]: 162 mg/dl). Orlistat was administered three times per day in conjunction with a hypocaloric diet After 6 months of treatment, body weight decreased by 17.71% and BMI decreased by 18.54%, whereas there was a significant (p < 0.01) improvement in serum lipid levels (total cholesterol: -25.33% LDL-C: -30.86%, high-density lipoprotein cholesterol: +9.37%, triglycerides: -35.97%). In conclusion, orlistat in combination with a low-energy diet seems to have a beneficial effect on body weight and lipid profile in overweight women with mild hypercholesterolemia.
在本研究中，我们调查了奥利司他6个月治疗对27名患有轻度高胆固醇血症（总胆固醇：225mg/dl；低密度脂蛋白胆固醇[LDL-C]：162mg/dl）的超重女性（平均体重指数[BMI]：27.5kg/m²；年龄中位数：38.4岁）体重和血脂水平的影响。奥利司他与低热量饮食相结合，每天服用三次。治疗6个月后，体重下降了17.71%，BMI下降了18.54%，而血清脂质水平有显著改善（p<0.01）（总胆固醇：-25.33%，LDL-C：-30.86%，高密度脂蛋白胆固醇：+9.37%，甘油三酯：-35.97%）。总之，奥利司他与低能量饮食联合使用似乎对患有轻度高胆固醇血症的超重女性的体重和血脂水平有有益影响。
