Salisbury Jeffrey L
Tumor Biology Program, Mayo Clinic, Rochester, MN 55905, USA.
Trends Cell Biol. 2003 Jul;13(7):340-3. doi: 10.1016/s0962-8924(03)00126-0.
The centrosome consists of a pair of centrioles and a surrounding matrix of pericentriolar material that anchors microtubule nucleation sites and consequently determines the number and organization of microtubules in interphase and mitotic cells. Recent studies utilizing a functional genomics approach in the nematode worm Caenorhabditis elegans and sophisticated light and electron microscopy techniques provide new insight into how centrioles act as centrosomal organizers and use a centriolar structural element to dictate centrosome size by defining their capacity to recruit pericentriolar material.
中心体由一对中心粒和周围的中心粒外周物质基质组成，该基质锚定微管成核位点，从而决定间期细胞和有丝分裂细胞中微管的数量和组织方式。最近，利用线虫秀丽隐杆线虫中的功能基因组学方法以及先进的光学和电子显微镜技术进行的研究，为中心粒如何作为中心体组织者发挥作用以及如何利用中心粒结构元件通过定义其募集中心粒外周物质的能力来决定中心体大小提供了新的见解。
