长期接触抗胆碱能药物会对阿尔茨海默病的病程产生不利影响。
Chronic exposure to anticholinergic medications adversely affects the course of Alzheimer disease.
作者信息
Lu Ching-ju, Tune Larry E
机构信息
Department of Psychiatry at Wesley Woods Geriatric Teaching and Research Hospital, Emory University School of Medicine, Atlanta, Georgia 30329-5102, USA.
出版信息
Am J Geriatr Psychiatry. 2003 Jul-Aug;11(4):458-61.
OBJECTIVE
Authors examined the effect of chronic exposure to anticholinergics in a cohort of Alzheimer disease (AD) patients.
METHODS
All patients were examined annually with standard neuropsychologic tests and received the cholinesterase inhibitor donepezil hydrochloride at a dose of 10 mg/day. The study population (N=69) was divided into two groups: those receiving one or more concomitant medications with significant anticholinergic properties (N=16) and those receiving no concomitant medications with anticholinergic properties (N=53).
RESULTS
At 2 years, MMSE scores were significantly worse for patients receiving anticholinergic medications than for those not on anticholinergics.
CONCLUSION
Although very preliminary, these data suggest that concomitant therapy with anticholinergics may be associated with significant deleterious effects on acetylcholinesterase therapy, or, more speculatively, that chronic exposure to anticholinergics may have adverse effects on the clinical course of AD.
目的
作者研究了长期接触抗胆碱能药物对一组阿尔茨海默病（AD）患者的影响。
方法
所有患者每年接受标准神经心理学测试，并接受剂量为10毫克/天的胆碱酯酶抑制剂盐酸多奈哌齐治疗。研究人群（N = 69）分为两组：接受一种或多种具有显著抗胆碱能特性的伴随药物的患者（N = 16）和未接受具有抗胆碱能特性的伴随药物的患者（N = 53）。
结果
在2年时，接受抗胆碱能药物治疗的患者的简易精神状态检查表（MMSE）得分显著低于未接受抗胆碱能药物治疗的患者。
结论
尽管这些数据非常初步，但表明抗胆碱能药物的联合治疗可能会对乙酰胆碱酯酶治疗产生显著有害影响，或者更具推测性地说，长期接触抗胆碱能药物可能会对AD的临床病程产生不利影响。
Zotero 插件