MacLennan David H, Kranias Evangelia G
Banting and Best Department of Medical Research, University of Toronto, Charles H. Best Institute, 112 College Street, Toronto, Ontario M5G 1L6, Canada.
Nat Rev Mol Cell Biol. 2003 Jul;4(7):566-77. doi: 10.1038/nrm1151.
Heart failure is a major cause of death and disability. Impairments in blood circulation that accompany heart failure can be traced, in part, to alterations in the activity of the sarcoplasmic reticulum Ca2+ pump that are induced by its interactions with phospholamban, a reversible inhibitor. If phospholamban becomes superinhibitory or chronically inhibitory, contractility is diminished, inducing dilated cardiomyopathy in mice and humans. In mice, phospholamban seems to encumber an otherwise healthy heart, but humans with a phospholamban-null genotype develop early-onset dilated cardiomyopathy.
心力衰竭是导致死亡和残疾的主要原因。心力衰竭伴随的血液循环障碍，部分可归因于肌浆网Ca2+泵活性的改变，这种改变是由其与一种可逆抑制剂受磷蛋白的相互作用所诱导的。如果受磷蛋白变得超抑制或长期抑制，心肌收缩力就会减弱，在小鼠和人类中诱发扩张型心肌病。在小鼠中，受磷蛋白似乎会阻碍原本健康的心脏，但具有受磷蛋白缺失基因型的人类会患上早发性扩张型心肌病。
