Hirao I, Kawai G, Kobayashi K, Nishimura Y, Miura K, Watanabe K, Ishido Y
Laboratory of Pharmaceutical Chemistry, Tokyo College of Pharmacy, Japan.
Nucleic Acids Symp Ser. 1992(27):127-8.
The deoxyribonucleotide fragments, d(GCGAAAGC) and d(GCGAAGC) form extraordinarily stable mini-hairpin structures containing only two G-C pairs. In contrast, the corresponding ribonucleotide fragments, r(GCGAAAGC) and r(GCGAAGC) are not so stable, although they also form mini-hairpin structures. The stability difference between these DNA and RNA mini-hairpins was examined by NMR studies and the molecular mechanics calculations, and by comparing with the stability of several sequence variants. Their stability was deduced to vary delicately depending on helical patterns formed by DNA (B form) and RNA (A form) structures.
脱氧核糖核苷酸片段d(GCGAAAGC)和d(GCGAAGC)形成了仅包含两个G-C对的极其稳定的小发夹结构。相比之下，相应的核糖核苷酸片段r(GCGAAAGC)和r(GCGAAGC)虽然也形成小发夹结构，但稳定性没那么高。通过核磁共振研究、分子力学计算以及与几个序列变体的稳定性进行比较，对这些DNA和RNA小发夹之间的稳定性差异进行了研究。据推断，它们的稳定性会根据由DNA（B型）和RNA（A型）结构形成的螺旋模式而微妙地变化。
