Origin of sequence specific cleavage of DNA by bleomycins.
作者信息
Kuroda R, Shinomiya M, Otsuka M
机构信息
Department of Chemistry, College of Arts and Sciences, University of Tokyo, Japan.
出版信息
Nucleic Acids Symp Ser. 1992(27):9-10.
PMID:1283919
Abstract
A new DNA photocleaving agent which contains bleomycin A2's DNA binding portion and its mono- and terthiazole analogues have been designed and synthesized, and their DNA binding mode and cleavage base specificity have been studied. The photoactive p-nitrobenzoyl group attached at the end of molecules cleaves DNA on UV irradiation. All the oligo-thiazole compounds exhibited high sequence specificity in DNA scission. The bithiazole derivative did not cleave DNA at or near 5'-GpT-3' or 5'-GpC-3' as expected from widely believed DNA binding mechanism of the antibiotics.
摘要
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