[心肌炎和扩张型心肌病中抗β1 - 肾上腺素能受体自身抗体：两个表位的定位]
[Autoantibodies against the beta 1-adrenergic receptor in myocarditis and dilated cardiomyopathy: localization of two epitopes].
作者信息
Wallukat G, Morwinski R, Magnusson Y, Hoebeke J, Wollenberger A
机构信息
Max Delbrück Centrum für molekulare Medizin, Berlin.
出版信息
Z Kardiol. 1992;81 Suppl 4:79-83.
Sera of patients with myocarditis and dilated cardiomyopathy contain stimulatory autoantibodies directed specifically against the beta 1-adrenergic receptor. The binding of the antibodies could be localized to either the first or the second extracellular loop of the beta 1-adrenoceptor. In 73% of the cases investigated the antibodies recognized the second extracellular loop. The agonistic effects of the antibodies were abolished by beta-adrenergic antagonists. Furthermore, the antagonists were able to remove the antibodies from their binding sites.
心肌炎和扩张型心肌病患者的血清中含有特异性针对β1 - 肾上腺素能受体的刺激性自身抗体。抗体的结合可定位于β1 - 肾上腺素能受体的第一个或第二个细胞外环。在所研究的病例中，73%的抗体识别第二个细胞外环。β - 肾上腺素能拮抗剂可消除抗体的激动作用。此外，拮抗剂能够将抗体从其结合位点上移除。
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