Wallukat G, Fu M L, Magnusson Y, Hjalmarson A, Hoebeke J, Wollenberger A
Max-Delbrück-Centre for Molecular Medicine, Berlin, Germany.
Blood Press Suppl. 1996;3:31-6.
Affinity-purified autoantibodies and anti-peptide antibodies directed against the second extracellular loop of the beta 1-adrenoceptor increase the beating rate of cultured cardiomyocytes just like the beta-adrenergic agonist isoprenaline. Their positive chronotropic action is blocked by beta-adrenergic antagonists. Affinity-purified autoantibodies and anti-peptide antibodies directed against the muscarinic cholinergic M2 receptor exert in these myocytes, like the muscarinic cholinergic agent carbachol, a negative chronotropic effect that is antagonized by atropine. In contrast to the agonism of isoprenaline and carbachol, the described agonistic effects of the antibodies are not subject to desensitization.
针对β1 -肾上腺素能受体第二个细胞外环的亲和纯化自身抗体和抗肽抗体，与β -肾上腺素能激动剂异丙肾上腺素一样，能提高培养心肌细胞的搏动率。它们的正性变时作用可被β -肾上腺素能拮抗剂阻断。针对毒蕈碱型胆碱能M2受体的亲和纯化自身抗体和抗肽抗体，在这些心肌细胞中，与毒蕈碱型胆碱能药物卡巴胆碱一样，产生负性变时效应，且该效应可被阿托品拮抗。与异丙肾上腺素和卡巴胆碱的激动作用不同，所述抗体的激动效应不会发生脱敏。
