Rutter Guy A, Da Silva Xavier Gabriela, Leclerc Isabelle
Henry Wellcome Laboratories of Integrated Cell Signalling and Department of Biochemistry, University Walk, University of Bristol, Bristol BS8 1TD, UK.
Biochem J. 2003 Oct 1;375(Pt 1):1-16. doi: 10.1042/BJ20030048.
AMPK (5'-AMP-activated protein kinase) is emerging as a metabolic master switch, by which cells in both mammals and lower organisms sense and decode changes in energy status. Changes in AMPK activity have been shown to regulate glucose transport in muscle and glucose production by the liver. Moreover, AMPK appears to be a key regulator of at least one transcription factor linked to a monogenic form of diabetes mellitus. As a result, considerable efforts are now under way to explore the usefulness of AMPK as a therapeutic target for other forms of this disease. Here we review this topic, and discuss new findings which suggest that AMPK may play roles in regulating insulin release and the survival of pancreatic islet beta-cells, and nutrient sensing by the brain.
AMPK（5'-腺苷酸活化蛋白激酶）正逐渐成为一种代谢主开关，通过它，哺乳动物和低等生物中的细胞能够感知并解读能量状态的变化。研究表明，AMPK活性的变化可调节肌肉中的葡萄糖转运以及肝脏中的葡萄糖生成。此外，AMPK似乎是与一种单基因形式糖尿病相关的至少一种转录因子的关键调节因子。因此，目前正在进行大量研究，以探索将AMPK作为这种疾病其他形式的治疗靶点的可行性。在此，我们综述这一主题，并讨论新的研究发现，这些发现表明AMPK可能在调节胰岛素释放、胰岛β细胞存活以及大脑的营养感知方面发挥作用。
