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[作为血管生成抑制剂的乙莫克舍]

[Emoxipin as an inhibitor of angiogenesis].

作者信息

Sologub A A, Akberova S I, Ziangirova G G

出版信息

Biull Eksp Biol Med. 1992 Dec;114(12):620-2.

PMID:1284038
Abstract

The effect of emoxypin on angiogenesis in rabbit cornea in aseptic inflammation induced by intracorneal implantation of a piece of quartz and on the development of the vessels of the chick embryo yolk sac was studied. 1% emoxypin pipetted thrice a day for 10-14 days inhibited corneal neovascularization and reduced the formation of new blood vessels. We observed an inhibitory effect on the development of vascular bed of the embryo yolk sac on incubation hour 64-72. The drug affected neither general growth of the embryos no the number of somites.

摘要

研究了艾莫昔平对兔角膜因植入石英片诱导的无菌性炎症中血管生成的影响,以及对鸡胚卵黄囊血管发育的影响。每天三次滴注1%艾莫昔平,持续10 - 14天,可抑制角膜新生血管形成并减少新血管的生成。我们观察到在孵育64 - 72小时时,艾莫昔平对胚卵黄囊血管床的发育有抑制作用。该药物对胚胎的总体生长和体节数量均无影响。

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