右丙亚胺——一种治疗蒽环类药物意外外渗的有前景的解毒剂。

Dexrazoxane-a promising antidote in the treatment of accidental extravasation of anthracyclines.

作者信息

Jensen Jesper Naested, Lock-Andersen Jørgen, Langer Seppo W, Mejer Johannes

机构信息

Department of Plastic and Reconstructive Surgery, Roskilde University Hospital, Roskilde, Denmark.

出版信息

Scand J Plast Reconstr Surg Hand Surg. 2003;37(3):174-5. doi: 10.1080/02844310310007791.

DOI:10.1080/02844310310007791

PMID:12841619

Abstract

Accidental extravasation of chemotherapy containing anthracycline often causes mutilating complications as a result of extensive tissue necrosis. Treatment therefore consists of extensive surgical debridement. We present the case of a 41-year-old woman with breast cancer who experienced extravasation of epirubicin. She was treated with an intravenous infusion of dexrazoxane for three successive days and recovered without surgical treatment and only slightly dysaesthesia in the surrounding tissue. Although infusion of dexrazoxane for this indication is still experimental we consider it a promising treatment for patients who have accidental extravasation of anthracyclines.

摘要

含蒽环类药物的化疗药物意外外渗常因广泛的组织坏死而导致致残性并发症。因此，治疗包括广泛的手术清创。我们报告了一例41岁乳腺癌女性发生表柔比星外渗的病例。她连续三天接受静脉输注右丙亚胺治疗，未接受手术治疗而康复，仅周围组织有轻微感觉异常。尽管将右丙亚胺用于该适应症仍处于试验阶段，但我们认为它对发生蒽环类药物意外外渗的患者是一种有前景的治疗方法。