硫辛酸对阿霉素诱导的大鼠高脂血症性肾毒性的影响。

The influence of lipoic acid on adriamycin-induced hyperlipidemic nephrotoxicity in rats.

作者信息

Malarkodi Kumaravel Palanichamy, Balachandar Andithangal Venkatesan, Varlakshmi Palaninathan

机构信息

Department of Medical Biochemistry, Dr. A.L.M. Post Graduate Institute of Basic Medical Sciences, University of Madras, Taramani Campus, Chennai, India.

出版信息

Mol Cell Biochem. 2003 May;247(1-2):139-45. doi: 10.1023/a:1024175325850.

DOI:10.1023/a:1024175325850

PMID:12841641

Abstract

Adriamycin widely used in the treatment of neoplastic conditions is nephrotoxic. In the present study the protective effect of lipoic acid was investigated in adriamycin-induced nephrotoxicity in adult male albino Wistar rats. Adriamycin-induced nephrotoxicity was characterized by hyperlipidemia, proteinuria, and hypoproteinemia, by decreased activities of the enzymes N-acetyl-beta-D-glucosaminidase and cathepsin D, by increased lipid peroxidation and decreases in serum catalase and glutathione activities, and by increased urinary and serum urea, creatinine and urinary glycosaminoglycans. Pretreatment with lipoic acid restored the changes, indicating that lipoic acid is renoprotective in adriamycin nephrotoxicity.

摘要

广泛用于治疗肿瘤疾病的阿霉素具有肾毒性。在本研究中，对成年雄性白化Wistar大鼠阿霉素诱导的肾毒性中硫辛酸的保护作用进行了研究。阿霉素诱导的肾毒性表现为高脂血症、蛋白尿和低蛋白血症，N-乙酰-β-D-氨基葡萄糖苷酶和组织蛋白酶D的活性降低，脂质过氧化增加，血清过氧化氢酶和谷胱甘肽活性降低，以及尿和血清尿素、肌酐和尿糖胺聚糖增加。硫辛酸预处理可恢复这些变化，表明硫辛酸对阿霉素肾毒性具有肾脏保护作用。