Wada T, Yasutomi M, Hashmura K, Kunikata M, Tanaka T, Mori M
Department of Surgery, Kinki University School of Medicine, Osaka, Japan.
Anticancer Res. 1992 Nov-Dec;12(6B):1973-82.
The distribution pattern of vimentin in mammary gland lesions, including benign lesions (36 cases) and adenocarcinomas (40 cases), was studied with the use of a monoclonal antibody. In myoepithelial cells of mastopathy, the positive vimentin staining was seen in 6 cases (33.3%). Gynecomastia showed strong vimentin expression in myoepithelial cells. Fibroadenomas (14 cases) expressed positive vimentin staining in 8 cases (57.1%) with various staining intensities in myoepithelial cells. Lactating mammary gland tissue was positive for vimentin staining in narrow myoepithelium. In adenocarcinoma, positive reactions in tumor cells were found in 17 cases (41.2%) of solid tubular, 12 cases (33.3%) of papillo-tubular, and 11 cases (54.5%) of scirrhous carcinomas. The staining intensity for vimentin was weak in modified myoepithelial cells and neoplastic cells. Malignant cells in mammary carcinomas with vimentin reactivity usually expressed keratin staining; thus a co-expression of vimentin and keratin was found in mammary carcinomas.
利用单克隆抗体研究波形蛋白在乳腺病变中的分布模式，包括良性病变（36例）和腺癌（40例）。在乳腺病的肌上皮细胞中，6例（33.3%）可见波形蛋白阳性染色。男性乳腺增生症显示肌上皮细胞中波形蛋白表达强烈。纤维腺瘤（14例）中，8例（57.1%）肌上皮细胞有波形蛋白阳性染色，染色强度各异。哺乳期乳腺组织在狭窄的肌上皮中波形蛋白染色呈阳性。在腺癌中，实性管状腺癌17例（41.2%）、乳头管状腺癌12例（33.3%）、硬癌11例（54.5%）的肿瘤细胞呈阳性反应。波形蛋白在化生的肌上皮细胞和肿瘤细胞中的染色强度较弱。具有波形蛋白反应性的乳腺癌恶性细胞通常表达角蛋白染色；因此，在乳腺癌中发现波形蛋白和角蛋白共表达。
