母胎界面的可溶性人类白细胞抗原G1——综述

Soluble HLA-G1 at the materno-foetal interface--a review.

作者信息

Le Bouteiller P, Legrand-Abravanel F, Solier C

机构信息

INSERM U563, Centre de Physiopathologie de Toulouse-Purpan, France.

出版信息

Placenta. 2003 Apr;24 Suppl A:S10-5. doi: 10.1053/plac.2002.0931.

DOI:10.1053/plac.2002.0931

PMID:12842408

Abstract

HLA-G differs from the other MHC class I genes. This includes a unique promoter region, a restricted constitutive tissular distribution, the translation of different membrane-bound and soluble isoforms, a shortened cytoplasmic tail and a minimal polymorphim. Soluble HLA-G1 is an immunosuppressive molecule inducing apoptosis of activated CD8(+) T cells and down-modulating CD4(+) T cell proliferation. Soluble HLA-G1 may also contribute to the control of implantation.

摘要

HLA - G与其他MHC I类基因不同。这包括一个独特的启动子区域、有限的组成性组织分布、不同膜结合和可溶性异构体的翻译、缩短的胞质尾以及最小的多态性。可溶性HLA - G1是一种免疫抑制分子，可诱导活化的CD8(+) T细胞凋亡并下调CD4(+) T细胞增殖。可溶性HLA - G1也可能有助于控制着床。