母体免疫系统对胎儿的耐受性：炎症介质在母胎界面的作用。
Tolerance of the fetus by the maternal immune system: role of inflammatory mediators at the feto-maternal interface.
作者信息
Kanellopoulos-Langevin Colette, Caucheteux Stéphane M, Verbeke Philippe, Ojcius David M
机构信息
Institut Jacques Monod, CNRS UMR 7592, Universités Paris 6 & 7, 2 place Jussieu, 75251 Paris Cedex 5, France.
出版信息
Reprod Biol Endocrinol. 2003 Dec 2;1:121. doi: 10.1186/1477-7827-1-121.
The adaptive immune system of placental mammals has evolved to tolerate the fetus. Rejection of the fetus by adaptive immune responses is therefore a rare event, with abortion being caused more frequently by inflammation in the placenta. This review will cover recent aspects of immune privilege and the innate immune system at the feto-maternal interface, citing examples of the role played by microbial infections in fetal demise.
胎盘哺乳动物的适应性免疫系统已经进化到能够耐受胎儿。因此，适应性免疫反应对胎儿的排斥是罕见事件，流产更常见的原因是胎盘炎症。本综述将涵盖胎儿-母体界面免疫特权和固有免疫系统的最新研究进展，并列举微生物感染在胎儿死亡中所起作用的实例。
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