Viazov S, Ratjen F, Scheidhauer R, Fiedler M, Roggendorf M
Institute of Virology, Essen University Hospital, D-45122 Essen, Germany.
J Clin Microbiol. 2003 Jul;41(7):3043-5. doi: 10.1128/JCM.41.7.3043-3045.2003.
RNA of the newly identified human metapneumovirus (HMPV) was detected in nasopharyngeal aspirates of 11 of 63 (17.5%) young children with respiratory tract disease. Markers of infection caused by another member of the Pneumovirinae subfamily of the family Paramyxoviridae, respiratory syncytial virus (RSV), were identified in 15 of these patients (23.8%). Three patients were simultaneously infected with HMPV and RSV. Studies of the clinical characteristics of HMPV-infected children did not reveal any difference between HMPV-infected patients and a control population of RSV-infected patients with regard to disease severity, but the duration of symptoms was significantly shorter for HMPV-infected patients. Phylogenetic analysis of the amplified viral genome fragments confirmed the existence and simultaneous circulation within one epidemic season of HMPV isolates belonging to two genetic lineages.
在63名患有呼吸道疾病的幼儿中,有11名(17.5%)的鼻咽抽吸物中检测到新发现的人偏肺病毒(HMPV)的RNA。在这些患者中的15名(23.8%)中发现了由副粘病毒科肺病毒亚科的另一个成员呼吸道合胞病毒(RSV)引起的感染标志物。3名患者同时感染了HMPV和RSV。对HMPV感染儿童的临床特征研究未发现HMPV感染患者与RSV感染患者的对照人群在疾病严重程度方面有任何差异,但HMPV感染患者的症状持续时间明显较短。对扩增的病毒基因组片段进行的系统发育分析证实,属于两个遗传谱系的HMPV分离株在一个流行季节内同时存在并传播。