Lu S M
Obstetric and Gynecologic Hospital, Zhejiang Medical University, Hangzhou.
Zhonghua Yi Xue Za Zhi. 1992 Oct;72(10):590-2, 638.
To investigate the effects of combination chemotherapy on ovarian cancer in vitro, we observed the sensitivity of tumors to different drugs by incorporation assay of tritium thymidine (3H-TdR). The results revealed that the drugs and their sensitive degrees varied from tumor to tumor. Whether the combination of the drugs is synergism or sometimes only enhances toxicity depends on the difference of individuals. We suggest that in vitro anti-cancer drug sensitivity test could be applied in selection or determination of chemotherapy protocol.
为了在体外研究联合化疗对卵巢癌的影响，我们通过氚胸腺嘧啶核苷（3H-TdR）掺入试验观察肿瘤对不同药物的敏感性。结果显示，不同肿瘤对药物及其敏感程度各不相同。药物联合是协同作用还是有时仅增强毒性取决于个体差异。我们建议体外抗癌药物敏感性试验可应用于化疗方案的选择或确定。
