Kawano H, Masuko S
Department of Anatomy, Saga Medical School, Japan.
Neurosci Lett. 1992 Dec 14;148(1-2):211-5. doi: 10.1016/0304-3940(92)90841-t.
The nucleus preopticus medianus (POMe) is known to be important for the regulation of fluid balance and cardiovascular control. Direct projections from the POMe to the paraventricular hypothalamic nucleus (PVN), where vasopressin-containing neurons exist, were examined in the rat using immunohistochemistry combined with a retrograde tract tracing method. After injection of WGA-HRP-colloidal gold into the PVN, many neurons were retrogradely labeled in the POMe; some of them were immunoreactive to Met-enkephalin-Arg6-Gly7-Leu8 (mE8) or substance P (SP). The results indicate that mE8- and SP-immunoreactive neurons in the POMe send their axons to the PVN.
已知视前正中核（POMe）对体液平衡调节和心血管控制很重要。在大鼠中，采用免疫组织化学结合逆行束路追踪法，研究了从POMe到下丘脑室旁核（PVN，此处存在含血管加压素的神经元）的直接投射。将WGA-HRP-胶体金注入PVN后，POMe中有许多神经元被逆行标记；其中一些对甲硫氨酸脑啡肽-精氨酸6-甘氨酸7-亮氨酸8（mE8）或P物质（SP）呈免疫反应性。结果表明，POMe中mE8和SP免疫反应性神经元将其轴突投射至PVN。
