Murakoshi M, Tagawa M, Inada R, Suzuki M
Safety Research Department, Teikoku Hormone Mfg. Co. Ltd., Kawasaki, Japan.
Tokai J Exp Clin Med. 1992 Oct;17(3-4):133-7.
The effects of testosterone (T) and 17 beta-estradiol (E2) on the prostate of castrated rats were investigated by histopathological and immunocytochemical procedures. A significant increase in prostatic weight occurred after 6 weeks treatment with T alone and in combination with E2. The greatest increase in prostatic weight occurred after the administration of T plus E2. Histopathologically, glandular hyperplasia of the prostate was noted, and the number of bromodeoxyuridine (BrdU)-positive cells showed a significant increase over that induced by testosterone alone.
通过组织病理学和免疫细胞化学方法研究了睾酮（T）和17β-雌二醇（E2）对去势大鼠前列腺的影响。单独使用T以及T与E2联合治疗6周后，前列腺重量显著增加。给予T加E2后，前列腺重量增加最大。组织病理学检查发现前列腺腺体增生，溴脱氧尿苷（BrdU）阳性细胞数量比单独使用睾酮时显著增加。
