Chopra Arun, Brown Kevin M, Rood Brian R, Packer Roger J, MacDonald Tobey J
Department of Pediatrics, Children's National Medical Center, Washington, DC 20010, USA.
Pediatr Neurosurg. 2003 Jul;39(2):68-74. doi: 10.1159/000071317.
Metastasis is the leading cause of treatment failure in medulloblastoma. Understanding the genetic regulation of metastasis may aid in the development of novel treatments. We therefore performed in silico analysis of the mRNA expression of 83 medulloblastomas compiled from two independent microarray studies by focusing on 135 genes most frequently linked to metastasis in other tumors. We then asked whether expression of these genes correlated with metastasis in the medulloblastoma array data sets. We found the platelet-derived growth factor receptor alpha, early growth response protein 1 and insulin-like growth factor 2 genes as well as several genes associated with MYCC and ERBB2 overexpressed by at least 2-fold in metastatic tumors in both array data sets. We conclude that these genes may interact to promote prometastatic signaling in medulloblastoma.
转移是髓母细胞瘤治疗失败的主要原因。了解转移的基因调控可能有助于开发新的治疗方法。因此，我们通过关注其他肿瘤中最常与转移相关的135个基因，对两项独立微阵列研究汇编的83个髓母细胞瘤的mRNA表达进行了计算机分析。然后，我们询问这些基因的表达是否与髓母细胞瘤阵列数据集中的转移相关。我们发现，在两个阵列数据集中，血小板衍生生长因子受体α、早期生长反应蛋白1和胰岛素样生长因子2基因，以及几个与MYCC和ERBB2相关的基因在转移性肿瘤中至少过表达2倍。我们得出结论，这些基因可能相互作用，促进髓母细胞瘤中的促转移信号传导。
