Bléoo Stacey L, Godbout Roseline, Rayner David, Tamimi Yahya, Moore Ronald B
Department of Surgery, Cross Cancer Institute, Edmonton, Alta., Canada.
Urol Int. 2003;71(1):118-21. doi: 10.1159/000071109.
We report a rare case of leiomyosarcoma in the bladder which occurred in an 18-year-old female with a prior history of retinoblastoma (RB). Molecular characterization of this tumor displayed a homozygous RB deletion and a reduced P53 expression. These results suggest that the loss of RB and P53 may have contributed to the initiation and/or progression of the leiomyosarcoma of the bladder in this patient.
我们报告了一例罕见的膀胱平滑肌肉瘤病例，该病例发生在一名18岁患有视网膜母细胞瘤（RB）病史的女性身上。对该肿瘤的分子特征分析显示存在RB基因纯合缺失以及P53表达降低。这些结果表明，RB和P53的缺失可能促成了该患者膀胱平滑肌肉瘤的发生和/或进展。
