急性色氨酸耗竭不会改变体感诱发电场。
Acute tryptophan depletion does not change somatosensory evoked magnetic fields.
作者信息
Kähkönen Seppo, Ahveninen Jyrki, Jääskeläinen Iiro P, Pennanen Sirpa, Liesivuori Jyrki, Nikulin Vadim V
机构信息
Cognitive Brain Research Unit, University of Helsinki, Helsinki, Finland.
BioMag Laboratory, Helsinki University Central Hospital, PO Box 340, 00290, Helsinki, Finland.
出版信息
Psychopharmacology (Berl). 2003 Nov;170(3):332-333. doi: 10.1007/s00213-003-1560-5. Epub 2003 Jul 4.
RATIONALE
Serotonin is shown to regulate the activity of primary auditory cortex, but little is known about serotonin modulation of other sensory cortices.
METHODS
We investigated somatosensory evoked magnetic fields (SEF) to left median nerve stimulation in eight healthy subjects in a double-blind, controlled, cross-over design study after acute tryptophan depletion (ATD) and control mixture. SEFs were recorded with the whole-head magnetoencephalography 6 h after ingestion of mixtures. The SEF sources and strength were estimated by a least-squares fit of a single equivalent current dipole.
RESULTS
ATD decreased the total and free TPR levels by 75 and 48% and control mixture increased them by 98% and 44%. ATD had no effect on the amplitudes or latencies of SEF components. The source locations of the responses were not significantly affected by ATD.
CONCLUSION
Serotonin does not affect stimuli processing in the primary somatosensory cortex.
原理
血清素可调节初级听觉皮层的活动，但血清素对其他感觉皮层的调节作用知之甚少。
方法
在一项双盲、对照、交叉设计研究中，我们对8名健康受试者在急性色氨酸耗竭（ATD）和对照混合物后，刺激左侧正中神经时的体感诱发电场（SEF）进行了研究。在摄入混合物6小时后，用全头磁脑电图记录SEF。通过单个等效电流偶极子的最小二乘拟合估计SEF的来源和强度。
结果
ATD使总TPR和游离TPR水平分别降低了75%和48%，对照混合物使其分别增加了98%和44%。ATD对SEF成分的振幅或潜伏期没有影响。ATD对反应的源位置没有显著影响。
结论
血清素不影响初级体感皮层中的刺激处理。
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