[化学试剂对小鼠腹腔巨噬细胞中溶酶体与吞噬体融合及F-肌动蛋白含量的影响]

[The effect of chemical agents on lysosome fusion with phagosomes and on the F-actin content in murine peritoneal macrophages].

作者信息

Mozhenok T P, Rpozanov Iu M, Solov'eva L V, Braun A D, Bulychev A G

出版信息

Tsitologiia. 1992;34(11-12):84-92.

Abstract

The influence of natural and synthetic polyamines, phalloidin, cytochalasin D, vinblastine, colchicine, puromycin, chlorpromazine, urea, glutaraldehyde, and ethanol on the phagosome-lysosome fusion and the content of F-actin in murine peritoneal macrophages has been studied. Fluorescent phallotoxin FITC-phalloidin was used to stain F-actin. Natural polyamines (spermine, spermidine, putrescine), phalloidin, ethanol (0.1 M) stimulated the phagosome-lysosome fusion and increased the mid-content of F-actin in macrophages. Cytochalasin D, vinblastine, colchicine, puromycin, chlorpromazine, urea, glutaraldehyde, ethanol (0.15 and 0.2 M) inhibited this process and decreased the mid-content of F-actin. Possible mechanisms of the interconnection of cytoskeleton and the phagosome-lysosome fusion are discussed.

摘要

研究了天然和合成多胺、鬼笔环肽、细胞松弛素D、长春碱、秋水仙碱、嘌呤霉素、氯丙嗪、尿素、戊二醛和乙醇对小鼠腹腔巨噬细胞吞噬体-溶酶体融合及F-肌动蛋白含量的影响。使用荧光鬼笔毒素FITC-鬼笔环肽对F-肌动蛋白进行染色。天然多胺（精胺、亚精胺、腐胺）、鬼笔环肽、乙醇（0.1 M）刺激吞噬体-溶酶体融合并增加巨噬细胞中F-肌动蛋白的含量。细胞松弛素D、长春碱、秋水仙碱、嘌呤霉素、氯丙嗪、尿素、戊二醛、乙醇（0.15和0.2 M）抑制此过程并降低F-肌动蛋白的含量。讨论了细胞骨架与吞噬体-溶酶体融合相互联系的可能机制。

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1

[The effect of chemical agents on lysosome fusion with phagosomes and on the F-actin content in murine peritoneal macrophages].[化学试剂对小鼠腹腔巨噬细胞中溶酶体与吞噬体融合及F-肌动蛋白含量的影响]

Tsitologiia. 1992;34(11-12):84-92.

2

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[Effect of some DNA-intercalators and antioxidants on the phagosome- lysosome fusion and F-actin content in murine peritoneal macrophages].[某些DNA嵌入剂和抗氧化剂对小鼠腹腔巨噬细胞吞噬体-溶酶体融合及F-肌动蛋白含量的影响]

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Effects of some biologically active compounds on phagosome-lysosome fusion in peritoneal macrophages of mice.某些生物活性化合物对小鼠腹腔巨噬细胞吞噬体-溶酶体融合的影响。

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Transient assembly of F-actin by phagosomes delays phagosome fusion with lysosomes in cargo-overloaded macrophages.吞噬体介导的F-肌动蛋白瞬时组装会延迟货物过载巨噬细胞中吞噬体与溶酶体的融合。

J Cell Sci. 2009 Aug 15;122(Pt 16):2935-45. doi: 10.1242/jcs.048355. Epub 2009 Jul 28.

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